Abstract: In the process of Sinicization of Marxism, Chinese excellent traditional culture played an important role. Chinese excellent traditional culture is the most basic cultural gene of every Chinese. As a party and state leader, Deng Xiaoping must carry this cultural gene on his body. And his outstanding political wisdom displayed on the stage of Chinese history must also be branded with the Chinese traditional culture. At present, the cause of socialism with Chinese characteristics initiated by Deng Xiaoping has entered a new era. This article will study the profound internal relationship between Deng Xiaoping's political wisdom and Chinese traditional culture from four aspects.