Abstract: Xi Jinping’s important exposition on the responsibility of young people in the new era, based on the big pattern, big history, and big era, from the three dimensions of value connotation, basic connotation and cultivation path, not only reveals the core meaning and essence of the youth’s mission in the new era, but also contains rich thinking and working methods, scientifically answer the major issues of the times for young people in the new era “why to take responsibility”, “what is to take responsibility” and “how to take responsibility”. Cultivating responsible young people in the new era is Xi Jinping’s ardent expectations and clear requirements based on the growth and development of young people. It has a long glorious tradition, a clear realistic orientation, and a profound value of the times; shoulder the responsibility for the people’s happiness, the nation’s destiny and a better world, what is Xi Jinping’s scientific interpretation of the rich connotation of youth responsibility in the new era; to cultivate the noble quality of being willing to take responsibility, to forge ahead with responsibility, and to create a growth environment that dares to take responsibility, are Xi Jinping’s profound answer to how to cultivate newcomers to the era who are responsible for national rejuvenation, and have clarified the pioneering force and practical path for realizing the Chinese dream of the great rejuvenation of the Chinese nation and promoting the construction of a community with a shared future for mankind.