Abstract: Guidance of network opinion is an important part of ideological and political education in colleges and universities. In recent years, the frequent occurrence of university network opinion events has aroused widespread public attention, which has brought great challenges to the security and stability of universities and the ideological and political education of students. Under the background of ideological and political education in universities in the new era, it’s a very urgent and realistic task for universities to grasp the law of network opinion guidance, improve the ability to guide and handle network opinion, and create a good education atmosphere. This paper analyzes the new requirements of ideological and political education for the guidance of university network opinion with cases, and then puts forward relevant strategies and suggestions.